Meiwen Cao（Professor）

  Name：

Meiwen Cao

Academic Title：

Professor

Advisor Type：

Doctoral Supervisor

  Department：

  College of Chemistry and Chemical   Engineering

Research Interests：

Applied Colloid and Interface Science

  E-Mail：

mwcao@upc.edu.cn

  Telephone：

13370855160

◎Educational Background

1999-2003, Shaanxi Normal University,   Department of Chemistry and Materials Science, Bachelor of Science

2003-2008, Institute of Chemistry   Chinese Academy of Sciences, Doctor of Science

2017-2018, The University of Manchester,   Academic Visitor

◎Work Experience

2008.7-2010.12, China University of   Petroleum (East China), Lecturer

2011.1-2022.11, China University of   Petroleum (East China), Associate Professor

2022.12 till now, China University of   Petroleum (East China), Professor

◎Research Direction

[1] Development of amphiphilic biomolecules   and their assembly to fabricate controlled structures and functionalities;

[2] Development of functional peptidic nanomaterials   and their application as drug/gene carriers

[3] Fabrication of composite materials   for application as biosensors and wearable devices

[4] Preparation of novel functional   nanomaterials and their application in pollutant prevention and removal

◎Research Project

[1] Construction of Cas9/sgRNA   ribonucleoprotein delivery vector based on polypeptide assembly, NSFC,   2022-2025, host.

[2] Artificial virus based on   peptide/DNA supramolecular assembly, NSFC, 2019-2022, host.

[3] Intracellular self-assembly of   amphiphilic peptides, NSFC, 2015-2018, host.

[4] Design, synthesis and properties of   peptide nucleic acid (PNA)-based amphiphilic molecules, NSFC, 2011-2013,   host.

[5] Design, synthesis and self-assembly   of Gemini amphiphilic molecules composed of complete amino acids, Shandong Natural   Science Foundation, 2010-2012, host.

[6] Structural and surface chemical   analysis of porous materials, China Academy of Atomic Energy, 2021-2022,   host.

[7] Formula optimization and analysis of   daily chemical products, P&G China (Beijing), 2021-2023, host.

[8] Formulation optimization and   analysis of oral care and toiletries, P&G China (Beijing), 2020-2022,   host.

[12] Study on formula stability of   laundry detergent, P&G China (Beijing), 2017-2018, host.

◎Representative Papers and Patents

1. Paper

1)          Zhang Q., Hu H., Fang P., Song Y., Wang S., Zhang Z., Cao M., et   al. Fabrication of polyphenol-etched amino acid-modified ZIF-8 and their   carbonic anhydrase-like catalytic activity. Colloids and Surfaces A2024,   682, 132882.

2)          Shen X., Cao M. Bicontinuous Interfacially Jammed Emulsion Gels   (Bijels): Preparation, Control Strategies, and Derived Porous Materials. Nanomaterials2024, 14, 574.

3)          Nanomaterials for Chemical Engineering (Volume II). (BOOK, Edited by   Meiwen Cao). Basel, Switzerland: MDPI; 2024. p. 297.

4)          Lu X., Liu Z., Wang X., Liu Y., Ma H., Cao M., et al.   Construction of MnO2@ZIF-8 core-shell nanocomposites for efficient removal of   Sr2+ from aqueous solution. Colloids and Surfaces A2024, 685,   133317.

5)          Lu X., Liu Z., Wang W., Wang X., Ma H., Cao M. Synthesis and   Evaluation of Peptide–Manganese Dioxide Nanocomposites as   Adsorbents for the Removal of Strontium Ions. Nanomaterials2024,   14, 52.

6)          Cao M. Recent Development of   Nanomaterials for Chemical Engineering. Nanomaterials2024, 14,   456.

7)          Wu J., Liu Y., Cao M.*, Zheng N., Ma H., Ye X., et al.:   Cancer-Responsive Multifunctional Nanoplatform Based on Peptide Self-Assembly   for Highly Efficient Combined Cancer Therapy by Alleviating Hypoxia and   Improving the Immunosuppressive Microenvironment. ACS Applied Materials & Interfaces2023, 15, 5667-5678.

8)          Wang W., Liu Z., Wang R., Cao M.*, Chen Y., Lu X., et al.: A   novel strategy for efficient removal of hazardous metal ions based on   thermoresponsive phase separation of the PNIPAM/GO system. Chemical Engineering Journal2023, 470, 143967.

9)          Shi Y., Nie Y., Xu H., Bi P., Chen B., Hou X., Cao M.*, et al.:   Fabrication of silane-based surface coating with Ag/TiO2 hybridization and   its anti-corrosion performance on metal surface. Colloids and Surfaces A2023,   676, 132241.

10)      Nanomaterials for Chemical Engineering (BOOK, Edited by Meiwen Cao).   Basel, Switzerland: MDPI; 2023. p.   302.

11)      Ji Z., Zhang Z., Lv W., Shi Y., Wang K., Ni S., Cao M.*, et al.:   Synthesis of ZIF-90 based nanozyme with excellent carbonic anhydrase   activity. Colloids and Surfaces A2023, 677, 132338.

12)      Cao M.*, Development of Functional   Nanomaterials for Applications in Chemical Engineering. Nanomaterials2023, 13, 609.

13)      Yang Y., Liu Z., Ma H., Cao M.*: Application of Peptides in   Construction of Nonviral Vectors for Gene Delivery, Nanomaterials2022, 12, 4076.

14)      Sun S., Xiang Y., Xu H., Cao M.*, Yu D.: Surfactant regulated   synthesis of ZIF-8 crystals as carbonic anhydrase-mimicking nanozyme. Colloids and Surfaces A2022, 648, 129103.

15)      Ma H., Cao M.*: Designed Peptide Assemblies for Efficient Gene   Delivery. Langmuir 2022, 38, 13627.

16)      Zhang, Q.; Liu, Y.; Xie, T.; Shang-guan, Y.; Tian, M.; Zhang, Q.; Cao   M.*: Sulfate ion-triggered self-assembly transitions of amphiphilic short   peptides by force balance adjustment. Colloids and Surfaces A2022,   637, 128252.

17)      Xu, X.; Liu, Y.; Yang, Y.; Wu, J.; Cao M.*; Sun, L.*: One-pot   synthesis of functional peptide-modified gold nanoparticles for gene   delivery. Colloids and Surfaces A 2022, 640, 128491.

18)      Sun, S.; Zhang, Z.; Xiang, Y.; Cao M.*; Yu, D.*: Amino   Acid-Mediated Synthesis of the ZIF-8 Nanozyme That Reproduces Both the   Zinc-Coordinated Active Center and Hydrophobic Pocket of Natural Carbonic   Anhydrase. Langmuir2022, 38 (4), 1621-1630.

19)      Cao M.*; Zhuang, Z.; Liu, Y.; Zhang,   Z.; Xuan, J.; Zhang, Q.; Wang, W., Peptide-mediated green synthesis of the   MnO2@ZIF-8 core–shell nanoparticles for   efficient removal of pollutant dyes from wastewater via a synergistic   process. Journal of Colloid and Interface Science 2022, 608   (3), 2779-2790.

20)      Cao M.*; Zhang, Z.; Zhang, X.; Wang,   Y.; Wu, J.; Liu, Z.; Sun, L.*; Wang, D.; Yue, T.*; Han, Y.; Wang, Y.; Wang,   Y.; Wang, M.*: Peptide Self-assembly into Stable Capsid-Like Nanospheres and   Co-assembly with DNA to Produce Smart Artificial Viruses. Journal of   Colloid and Interface Science2022, 615, 395-407.

21)      Tian, M.; Chen, X.; Zhang, Q.; Zou, X.; Ma, D.; Xuan, J.; Wang, W.; Cao   M.*: Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8:   Effect of Molecular Hydrophobicity, Charge Number and Charge Location. Nanomaterials2021, 11 (10), 2665.

22)      Nie, Y.; Tian, M.; Zhang, Q.; Wang, L.; Ji, Z.; Chen, X.; Yang, S.;   Song, W.; Wu, C.; Xu, H.; Cao M.*: Controlled fabrication of   biocompatible graphene oxide Langmuir–Blodgett films by size and   surface property manipulation. Journal of Dispersion Science and   Technology2021, 1-12.

23)      Nie, Y.; Ma, S.; Tian, M.; Zhang, Q.; Huang, J.; Cao M.*; Li, Y.;   Sun, L.; Pan, J.; Wang, Y.; Bi, P.*; Xu, H.; Zeng, J.*; Wang, S.; Xia, Y.: Superhydrophobic   silane-based surface coatings on metal surface with nanoparticles hybridization   to enhance anticorrosion efficiency, wearing resistance and antimicrobial   ability. Surface and Coatings Technology2021, 410,   126966.

24)      Li, Y.; Ma, S.; Fang, X.; Wu, C.; Chen, H.; Zhang, W.; Cao M.*;   Liu, J.*: Water Hardness Effect on the Association and Adsorption of Cationic   Cellulose Derivative/Anionic Surfactant Mixtures for Fabric Softener   Application. Colloids and Surfaces A2021, 626, 127031.

25)      Li, J.; Li, Z.; Cao M.*; Liu, J.*: Expression and   characterization of catechol 1,2-dioxygenase from Oceanimonas marisflavi   102-Na3. Protein Expr Purif2021, 188, 105964.

26)      Cao M.*; Shen, Y.; Yan, Z.; Wei, Q.;   Jiao, T.; Shen, Y.; Han, Y.; Wang, Y.; Wang, S.; Xia, Y.; Yue, T.*: Extraction-like   removal of organic dyes from polluted water by the graphene oxide/PNIPAM   composite system. Chemical Engineering Journal2021, 405,   126647.

27)      Xuan, J.; Liu, Y.; Xu, X.; Ding, Z.; Zhuang, Z.; Zhang, Y.; Yan, Y.; Cao   M.*; Wang, S.; Xia, Y.; Sun, L.*: Peptide-Mediated Synthesis of Zeolitic   Imidazolate Framework-8 with Controllable Morphology and Size. Langmuir2020, 36 (46), 13981-13988.

28)      Xiu, Y.; Xu, L.; Zhang, X.; Wang, X.; Liu, F.; Xia, Y.; Cao M.*;   Wang, S.*: Mechanistic Process Understanding of the Biomimetic Construction   of Porphyrin-Based Light-Capturing Antennas from Self-Assembled Fmoc-Blocked   Peptide Templates. ACS Sustainable Chemistry & Engineering2020,   8 (41), 15761-15771.

29)      Wang, Y.; Xuan, J.; Zhao, W.; Ding, Z.; Zhang, L.; Du, R.; Zhang, A.;   Wang, Y.; Li, D.; Cao M.*: Smart and selective cancer-killing peptides   with cell penetrating sequence and dual-targeting mechanism. Colloids and   Surfaces A2020, 586, 124185.

30)      Wang, Y.; Nie, Y.; Ding, Z.; Yao, M.; Du, R.; Zhang, L.; Wang, S.; Li,   D.; Wang, Y.; Cao M.*: An Amphiphilic Peptide with Cell Penetrating   Sequence for Highly Efficient Gene Transfection. Colloids and Surfaces A2020, 590, 124529.

31)      Xu, X.; Liu, Y.; Fu, W.; Yao, M.; Ding, Z.; Xuan, J.; Li, D.; Wang, S.;   Xia, Y.; Cao M.*: Poly(N-isopropylacrylamide)-Based Thermoresponsive   Composite Hydrogels for Biomedical Applications. Polymers2020,   12, 580.

32)      Nie, Y.; Huang, J.; Ma, S.; Li, Z.; Shi, Y.; Yang, X.; Fang, X.; Zeng,   J.; Bi, P.*; Qi, J.; Wang, S.; Xia, Y.; Jiao, T.*; Li, D.; Cao M.*: Aplplied   Surface Science2020, 527, 146915.

33)      Meng, Y.; Yin, J.; Jiao, T.*; Bai, J.; Zhang, L.; Su, J.; Liu, S.; Bai, Z.;   Cao M.*; Peng, Q.*: Self-assembled copper/cobalt-containing   polypyrrole hydrogels for highly efficient ORR electrocatalysts. Journal   of Molecular Liquids2020, 298, 112010.

34)      Wang, Y.; Xuan, J.; Zhao, W.; Ding, Z.; Zhang, L.; Du, R.; Zhang, A.;   Wang, Y.; Li, D.; Cao M.*: Smart and   selective cancer-killing peptides with cell penetrating sequence and   dual-targeting mechanism. Colloids and   Surfaces A2020, 586, 124185.

35)      Wang, Y.; Nie, Y.; Ding, Z.; Yao, M.; Du, R.; Zhang, L.; Wang, S.; Li,   D.; Wang, Y.; Cao, M.*: An Amphiphilic Peptide with Cell Penetrating   Sequence for Highly Efficient Gene Transfection. Colloids and Surfaces A2020,   590, 124529.

36)      Cao M.*; Wang, Y.; Hu, X.; Gong, H.;   Li, R.; Cox, H.; Zhang, Jing.; Waigh, T. A.; Xu, H.; Lu, J. R.: Reversible   Thermoresponsive Peptide-PNIPAM Hydrogels for Controlled Drug Delivery. Biomacromolecules   2019, DOI: 10.1021/acs.biomac.9b01009.

37)      Cao M.*; Xing, R.; Chang, R.; Wang, Y.;   Yan, X.*: Peptide-coordination self-assembly for the precise design of   theranostic nanodrugs. Coordination Chemistry Reviews2019, 397,   14-27.

38)      Cao M.*; Lu, S.; Wang, N.; Xu, H.*;   Cox, H.; Li, R.; Waigh, T.; Han, Y.; Wang, Y.; Lu, J. R.*: Enzyme-Triggered   Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug   Delivery and Enhanced Cancer Therapy. Applied   Materials & Interfaces2019,   11, 16357-16366.

39)      Cao M.*; Shen, Y.; Wang, Y.; Wang, X.;   Li, D.: Self-Assembly of Short Elastin-like Amphiphilic Peptides: Effects of   Temperature, Molecular Hydrophobicity and Charge Distribution. Molecules2019, 24, 202.

40)      Cao M.*; Wang, Y.; Zhao, W.; Qi, R.;   Han, Y.; Wu, R.; Wang, Y.; Xu, H.*: Peptide-Induced DNA Condensation into   Virus-Mimicking Nanostructures. ACS   Applied Materials & Interfaces2018,   10, 24349-24360.

41)      Cao M.*; Zhao, W.; Wang, L.; Li, R.; Gong, H.; Zhang, Y.; Xu, H.; Lu, J. R.*:   Graphene Oxide-Assisted Accumulation and Layer-by-Layer Assembly of   Antibacterial Peptide for Sustained Release Applications. ACS Applied Materials & Interfaces2018, 10, 24937-24946.

42)      Cao M.; Lu, S.; Zhao, W.; Deng, L.;   Wang, M.; Wang, J.; Zhou, P.; Wang, D.; Xu, H.*; Lu, J. R.*: Peptide   Self-Assembled Nanostructures with Distinct Morphologies and Properties   Fabricated by Molecular Design. ACS   Applied Materials & Interfaces2017,   9, 39174-39184.

43)      Cao M.*; Zhao, W.; Zhou, P.; Xie, Z.;   Sun, Y.; Xu, H.*: Peptide nucleic acid-ionic self-complementary peptide   conjugates: highly efficient DNA condensers with specific condensing   mechanism. RSC Advances2017, 7, 3796-3803.

44)      Cao M.; Wang, N.; Wang, L.; Zhang, Y.;   Chen, Y.; Xie, Z.; Li, Z.; Pambou, E.; Li, R.; Chen, C.; Pan, F.; Xu, H.*;   Penny, J.; Webster, J. R. P.; Lu, J. R.*: Direct exfoliation of graphite into   graphene in aqueous solutions of amphiphilic peptides. Journal of Materials Chemistry B2016, 4, 152-161.

45)      Cao M.*; Wang, N.; Zhou, P.; Sun, Y.;   Wang, J.; Wang, S.; Xu, H.: Virus-like supramolecular assemblies formed by   cooperation of base pairing interaction and peptidic association. Science China Chemistry2016, 59, 310-315. （SCI二区，IF：4.448）

46)      Cao M.*; Cao, C.; Zhou, P.; Wang, N.;   Wang, D.; Wang, J.; Xia, D.; Xu, H.*: Self-assembly of amphiphilic peptides:   Effects of the single-chain-to-gemini structural transition and the side   chain groups. Colloids and Surfaces A2015, 469, 263-270.

47)      Cao M.*; Deng, L.; Xu, H.*: Study of   PNA–DNA hybridization by AFM-based single-molecule force spectroscopy. Colloids and Surfaces A2015, 470, 46-51.

48)      Cao M.*; Cao, C.; Zhang, L.; Xia, D.;   Xu, H.*: Tuning of peptide assembly through force balance adjustment. Journal of Colloid and Interface Science2013, 407, 287-295.

49)      Cao M.; Wang, Y. M.; Ge, X.; Cao, C.   H.; Wang, J.; Xu, H.; Xia, D. H.; Zhao, X. B.; Lu, J. R.: Effects of Anions   on Nanostructuring of Cationic Amphiphilic Peptides. Journal of Physical Chemistry B2011, 115, 11862-11871.   

50)      Cao M.; Wang, X. L.: Effect of   Surfactant Addition on the Structure of Silver Aggregates Produced by   Galvanic Cell Reaction and Fabrication of Superhydrophobic Surfaces. Journal of Dispersion Science and   Technology2010, 31, 703-708.

51)      Cao M.; Wang, X. L.: Direct   Observation and Distinction of the Inner/Outer Layers of Surfactant Bilayer   Formed at the Solid/Solution Interface. Journal   of Dispersion Science and Technology2010,   31, 38-43.

52)      Cao M.; Deng, M. L.; Wang, X. L.;   Wang, Y. L.: Decompaction of Cationic Gemini Surfactant-Induced DNA   Condensates by beta-Cyclodextrin or Anionic Surfactant. Journal of Physical Chemistry B2008, 112, 13648-13654.

53)      Cao M.; Han, Y. C.; Wang, J. B.; Wang,   Y. L.: Modulation of fibrillogenesis of amyloid beta(1-40) peptide with   cationic gemini surfactant. Journal of   Physical Chemistry B2007, 111, 13436-13443.

54)      Cao M.; Wang,   J. B.; Wang, Y. L.: Surface patterns induced by Cu2+ ions on BPEI/PAA   layer-by-layer assembly. Langmuir2007, 23, 3142-3149.

55)      Cao M.; Song, X. Y.; Wang, J. B.;   Wang, Y. L.: Adsorption of hexyl-alpha,omega-bis(dodecyl- dimethylammonium   bromide) gemini surfactant on silica and its effect on wettability. Journal of Colloid and Interface Science2006, 300, 519-525.

56)      Cao M.; Song, X. Y.; Zhai, J.; Wang,   J. B.; Wang, Y. L.: Fabrication of highly antireflective silicon surfaces   with superhydrophobicity. Journal of   Physical Chemistry B2006, 110, 13072-13075.

2.Patent

1)          Application of a composite hydrogel in removal of heavy   metal ions (ZL201910328332.5)

2)          A stripped hydrogel for removal of surface contaminants   (ZL202010630656.7)

3)          Gene and chemical drug co transport vector and its   application method (ZL201811307307.0)

4)          Application of mxene/silane surface composite silane   film in metal corrosion protection (ZL201910931909.1)

5)          A self-assembled peptide and its application as DNA   coagulation reagent (ZL201710223138.1)

6)          An amphiphilic polypeptide molecule that can be used as   a gene carrier (ZL201710117069.6)

7)          Preparation and application of temperature responsive   inverse hydrogels (ZL201810373751.6)

8)          An enzyme responsive self-assembled peptide and its   application (ZL201710223136.2)

9)          Antitumor polypeptide molecule with dual targeting and   selectivity and its application (ZL201710499462.6)

10)    A   self-assembled antibacterial peptide (ZL201610265536.5)

11)    A long-acting   slow-release antibacterial film with high drug loading and its preparation   method (ZL201510794371.6)

12)    A preparation   method of graphene dispersant and graphene dispersion (ZL201410532476. X)

13)    Preparation of   a high strength polypeptide hydrogel (ZL201510697529.8)

14)    A method to   increase wellbore stability and reduce filtration (ZL201410502665.2)

◎Awards and Honors

[1] December 2020, the first prize of Scientific   and Technological Progress Award of Xinjiang Uygur Autonomous Region (ranking   fifth);

[2] November 2021, won the title of   Outstanding Young Talent in Qingdao West Coast New District.

◎Courses Offered

Undergraduate：《Introduction to   Bioengineering》《Production Practice》《Nanotechnology and Human Life》《Macro-,   meso- and micro- world》

Postgraduate：《Supramolecular   Chemistry》《Biotechnology Pharmaceutical》《Biological Instrument Analysis Technology》《Advances in Life Science and Biotechnology》

◎Student Training

1.Supervise Postgraduate Students

There are five   academic postgraduates and twelve professional postgraduates under   independent guidance. There are eight graduate students, including five   working in enterprises, two working in junior and senior high schools and one   working in government departments. Assist in guiding one doctoral student and   hree master students.

2.Typical student：

(1) In 2021, Xu Xiaomin, Liu Yang and   Ding Zhen won the Outstanding achievement   Award of Graduate Students in Shandong Province;

(2) In October 2021, Nie Yan's   graduation thesis preparation of organosilane hybrid functional coating   on metal surface won the Excellent Master's Thesis of the University;

(3) In 2021, Xu Xiaomin, Liu Yang, Ding   Zhen, Xuan Jiaming and other students' research paper poly   (n-isopropylamide)-based thermosponsive composite hydrogels for biomedical   applications, polymers, 12 (3), 580 was highly rated and cited;

(4) In June 2020, Shenyang won the title   of Outstanding Graduate of Shandong Province and entered Qingdao   Environmental Protection Department;

(5) After graduation, Xie Zilong entered   North China Pharmaceutical Group and won the honor of Excellent Intern of   North China Pharmaceutical in 2017-2018 and the title of Excellent May Day Worker   in 2019;

(6) Lu Sha, Shenyang, Nie Yan, Liu Zhen,   Xu Xiaomin and other students won the titles of Excellent GraduateStudent, Excellent Student Cadre,   Excellent League Member and so on;

(7) Wang Yu, Lu Sha, Shenyang, Nie Yan,   Xu Xiaomin, Liu Yang and other students won many academic scholarships of   different levels.

3.Admissions Instructions：

Enrollment major: Biochemistry (Master   degree), Biology and Medicine (Master degree)

Admission requirements: proactive,   responsible and serious, strong teamwork ability, good communication skills   and excellent English levels.

◎Part-time Academic Job

[1] Served as Guest Editor of   world-class academic journal Nanomaterials and Review Editor of Frontier in Bioengineering   and Biotechnology;

[2] Served as the communication   evaluation expert of National Natural Science Foundation of China and the   evaluation expert of Graduate Dissertations of the Ministry of education;

[3] Reviewers of   journals such as ACS Appl Mater. Interfaces, Anal. Chem., Langmuir, J.   Phys. Chem. B., Collaids & Surfaces A and so on.

[4] Member of Chinese Chemical Society   and Chinese chemical society.